Transition Zone Migration: A Mechanism for Cytoplasmic Ciliogenesis and Postaxonemal Centriole Elongation
نویسندگان
چکیده
منابع مشابه
Human CPAP and CP110 in centriole elongation and ciliogenesis
SUMMARY 1. SUMMARY Centrioles are the major components of centrosomes, which organize a wide range of microtubule (MT)-dependent processes in proliferating cells, and function as basal bodies for primary cilia formation in quiescent cells. Centrioles and basal bodies are structurally similar, barrel-shaped organelles composed of MTs and are associated with multiple proteins. In proliferating ce...
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Cilia, either motile or immotile, exist on most cells in the human body. There are several different mechanisms of ciliogenesis, which enable the production of many kinds of cilia and flagella: motile and immotile, transient and long-lived. These can be linked to the cell cycle or associated with differentiation. A primary cilium is extended from a basal body analogous to the mitotic centrioles...
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ove over, vesicles. Intermediate filaments (IFs) are also a major cargo of microtubule-based motor proteins, according to new results from Helfand et al. on page 795. The results M explain how rapid changes in IF structure are produced by transport of nonfilamentous vimentin particles. Dynamic changes in vimentin IF structure occur at the onset of cell spreading, requiring the transport of vime...
متن کاملCEP295 interacts with microtubules and is required for centriole elongation
Centriole duplication is a tightly ordered process during which procentrioles are assembled in G1-S and elongate during S and G2. Here, we show that human CEP295 (Drosophila Ana1) is not essential for initial cartwheel assembly, but is required to build distal half centrioles during S and G2. Using super-resolution and immunogold electron microscopy, we demonstrate that CEP295 is recruited to t...
متن کاملDrosophila Ana1 is required for centrosome assembly and centriole elongation
Centrioles organise centrosomes and cilia, and these organelles have an important role in many cell processes. In flies, the centriole protein Ana1 is required for the assembly of functional centrosomes and cilia. It has recently been shown that Cep135 (also known as Bld10) initially recruits Ana1 to newly formed centrioles, and that Ana1 then recruits Asl (known as Cep152 in mammals) to promot...
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ژورنال
عنوان ژورنال: Cold Spring Harbor Perspectives in Biology
سال: 2017
ISSN: 1943-0264
DOI: 10.1101/cshperspect.a028142